What confers specificity on glycine for its receptor site?
نویسندگان
چکیده
منابع مشابه
On the true affinity of glycine for its binding site at the NMDA receptor complex.
To determine the exact potency of inhibitors acting at the glycine site of the NMDA receptor complex using [3H]glycine as a radioligand, the true equilibrium constant (KD) of the radioligand has to be known. To achieve this goal, (1) the contamination of water by glycine was studied, (2) the true affinity of glycine for the NMDA receptor was estimated by different methods, and (3) the inhibitio...
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Listeria monocytogenes is a gram-positive food-borne pathogen that is notably resistant to osmotic stress and can grow at refrigerator temperatures. These two characteristics make it an insidious threat to public health. Like several other organisms, L. monocytogenes accumulates glycine betaine, a ubiquitous and effective osmolyte, intracellularly when grown under osmotic stress. However, it al...
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Glycinergic and GABAergic inhibition are juxtaposed at one retinal synaptic layer yet likely perform different functions. These functions have usually been evaluated using receptor antagonists. In examining retinal glycine receptors, we were surprised to find that commonly used concentrations of GABA antagonists blocked significant fractions of the glycine current. In retinal amacrine and gangl...
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In the mammalian cortex, 2 subunit-containing glycine receptors (GlyRs) mediate tonic inhibition, but the precise functional role of this type of GlyRs is difficult to establish because of the lack of subtype-selective antagonist. In this study, we found that cyclothiazide (CTZ), an epileptogenic agent, potently inhibited GlyR-mediated current (IGly) in cultured rat hippocampal neurons. The inh...
متن کاملAlpha2 subunit specificity of cyclothiazide inhibition on glycine receptors.
In the mammalian cortex, alpha2 subunit-containing glycine receptors (GlyRs) mediate tonic inhibition, but the precise functional role of this type of GlyRs is difficult to establish because of the lack of subtype-selective antagonist. In this study, we found that cyclothiazide (CTZ), an epileptogenic agent, potently inhibited GlyR-mediated current (I(Gly)) in cultured rat hippocampal neurons. ...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1989
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1989.tb11961.x